||Sturgeon is a high price and very popular food fish in the worldwide. With the economic development of oversea Chinese, the consumption of sturgeon is increasing and shows great growth potential. However, the sturgeon culturing requires strict conditions in the water temperature and water quality. In Taiwan, the increasing environmental temperature in recent years and the Sterptococcosis/ Aeromonasis-induced diseases which are tend to occur in summer have become the major challenges in sturgeon culturing. The aim of this study is to investigate the current status and bottleneck in domestic sturgeon culturing, and then develop the optimal formula of artificial diet and establish the techniques for production management and disease prevention through the experiments in hybrid sturgeon (Huso huso♀× Acipenser ruthenus♂). The results showed that the immunostimulant additive could effectively increase the immunity and survival, and the culturing standard operating procedure we built did improve the survival rate in the sturgeon culturing farm we counseled. By popularizing these culturing techniques, we expect it will increase the economic margin for farmers, and achieve the long term sustainability for Taiwanese farming industry.